Uric acid liposomes
AssigneeFreeOx Biotech, S.L.
InventorPedro RAMOS CABRER
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Abstract
A liposome that encapsulate uric acid wherein the liposome has a lipid bilayer and wherein the uric acid is obtained without the use of lithium or potassium ions; methods for its preparation and uses thereof.
Claims14
A liposome that encapsulates uric acid, wherein said liposome has a lipid bilayer comprising double-chain phospholipids and positively charged cholesterol, and wherein said liposome is unilamellar, wherein the uric acid is obtained by preparing a solution of co-crystals of uric acid as starting material without lithium or potassium ions.
A method for the manufacture of liposomes that encapsulate uric acid, comprising the steps of:
- a. preparing a solution of co-crystals of uric acid with L-lysine in purified water;
- b. adjusting the pH of the solution to a value between 7.2 and 7.4;
- c) forming a lipid film;
- d) rehydrating the lipid film formed in step c) with the uric acid solution of step b) to obtain liposomes;
- e) extruding the liposomes of step d) using purified water as solvent;
- and
- f) filtering the liposomes obtained in step e) using purified water as solvent, wherein steps c) to f) are carried out free of calcium ions.
Dependencies are inferred from the claim text.