Methods of suppressing free dna and compositions thereof
AssigneePS Therapy Ltd.
InventorSiddharth Narendran
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Abstract
The present invention provides methods of suppressing, sequestering and/or removing free DNA in and from the eye of a subject comprising topically administering a composition of the present invention to the eye of the subject in need thereof. The present invention is further directed to ophthalmic compositions that are capable of suppressing, sequestering and/or removing free DNA from the eye.
Claims22
A method of suppressing free DNA in the eye of a subject in need thereof comprising topically administering to the subject in need thereof a composition comprising one or more nonionic surfactants, one or more viscosity enhancers, one or more cyclodextrins and water.
A method of suppressing free DNA in the eye of a subject in need thereof comprising topically administering to the subject in need thereof a composition comprising from about 0.5% to about 5% w/w of one or more nonionic surfactants, from about 0.01% to about 5% w/w of one or more viscosity enhancers, from about 1% to about 2% w/w of one or more cyclodextrins and water, wherein w/w denotes weight by total weight of the composition.
A method of treating an eye condition comprising topically administering to a subject in need thereof a composition comprising one or more nonionic surfactants, one or more viscosity enhancers, one or more cyclodextrins and water, wherein the eye condition is caused by or is associated with free DNA.
An ophthalmic composition for suppressing free DNA comprising polysorbate 80, poloxamer 407, poloxamer 188, polyoxyl castor oil, polyethylene glycol 400, mannitol, hydroxypropylmethyl cellulose, hydroxypropyl gamma-cyclodextrin, dendrimer and water.
Dependencies are inferred from the claim text.