Devices, systems, and methods for separation and/or enrichment of particles in solution

A system for separation of particles in a liquid sample, the system comprising:

• a substrate;
• a containment structure disposed on the substrate and defining a fluid-retaining region configured to contain a fluid;
• one or more acoustic transducers coupled to the substrate and configured to provide acoustic waves to the fluid such that the fluid is rotated by the acoustic waves;
• and
• a disc comprising a plurality of microfluidic channels, the disc configured to be disposed on top of the fluid and rotate with the fluid, the plurality of microfluidic channels configured to receive the liquid sample,
• wherein rotation of the disc establishes a centrifugal field and an induced fluid flow within the plurality of microfluidic channels to transport particles within the liquid sample along the plurality of microfluidic channels at velocities dependent on one or more of particle size and particle density, thereby effecting separation and/or enrichment of a selected particle fraction of the liquid sample.