Neurotensin receptor 1 (ntsr1) targeted therapeutics and uses thereof

A compound of the following chemical formula, or a pharmaceutically acceptable salt thereof:

• wherein:
• R1a, R1b, R1c, and R1d are each independently selected from the group consisting of —F, —Cl, —Br, —I, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, —CF3, —CN, —CO2H, —CO2CH3, —C(═O)NR3R4, —CH(═N)OH, —NR5R6, —NO2, —NR7C(═O)R8, —NR9C(═O)OR0, and —OC(═O)NR11R12;
• R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are each independently —H or —CH3;
• each R2 is independently selected from the group consisting of —F, substituted or unsubstituted C1-C6 alkyl, —CF3, or —CN, or two R2 variables on the same or adjacent carbon atoms come together to form an unsubstituted C3-C6 cycloalkyl ring;
• y is 1 or 2;
• z is 1 or 2;
• q is 0, 1, 2, 3, 4, 5, 6, 7, or 8;
• W is —C(Rr)— or —N— and Y is —C(Rs)— or —N—;
• wherein Rr and Rs are each independently selected from the group consisting of:
• hydrogen, —F, —Cl, —Br, —CF3, —C1-C6 alkyl, and —O—C1-C6 alkyl;
• V is —C(Rx)— or —N— and Z is —C(Ry)— or —N—, wherein Rx and Ry are each independently selected from the group consisting of:
• —F, —Cl, —Br, —CF3, —C1-C6 alkyl, or —O—C1-C6 alkyl;
• Rz is
• L is a linker;
• and
• Ra is a chelating moiety or a radionuclide complex thereof.