Ophthalmic artery angioplasty balloon and guidewire based intra vascular lithotripsy (ivl) for treatment of ophthalmic diseases

A method of treating lesions and/or calcifications within vasculature behind an eye of a subject using an intra vascular lithotripsy (IVL) device, the IVL device comprising a guidewire for accessing vasculature of the subject, a balloon catheter including an inflatable balloon configured to be placed within a treatment area of the vasculature of the subject and to be inflated therein, and an electrode arrangement within the balloon, the method comprising:

• accessing an ophthalmic artery (OA) of the subject using the guidewire;
• placing the balloon within a treatment area near an internal carotid artery (ICA) or within the OA;
• inflating the balloon a first time within the treatment area;
• and
• supplying electrical energy to the electrode arrangement, thereby initiating and delivering one or more shock waves to the treatment area.

An intra vascular lithotripsy (IVL) device for treatment of lesions and/or calcifications within vasculature behind an eye of a subject, the IVL device comprising:

• a hypotube;
• a guidewire configured to access the vasculature of the subject, a proximal portion of the guidewire being housed within the hypotube;
• and
• an electrode arrangement within the guidewire,
• wherein, the electrode arrangement is configured to deliver one or more shock waves, through the guidewire and the hypotube, and to a treatment area, when electrical energy is supplied to the electrode arrangement.