Systems and methods for accelerated online adaptive radiation therapy

A method for assessing a quality of a radiation treatment plan, the method comprising:

• (a) accessing with a computer system, a first radiation treatment plan for a subject, wherein the first radiation treatment plan includes a first three-dimensional dose map;
• (b) accessing with the computer system, a second radiation treatment plan for the subject, wherein the second radiation treatment plan includes a second three-dimensional dose map;
• (c) generating at least one spatial dose feature based on the first three-dimensional dose map and the second three-dimensional dose map;
• and
• (d) selecting as a higher quality radiation treatment plan one of the first radiation treatment plan or the second radiation treatment plan based on an analysis of the at least one spatial dose feature.