Conjugates comprising antifungals and casein kinase (ck1) inhibitors and methods of use thereof

A conjugate compound of Formula (I) or an enantiomer thereof, or a pharmaceutically acceptable salt, solvate and/or prodrug thereof,

• wherein:
• A is a moiety that increases fungal cell uptake and/or fungal cell permeability;
• B is a CK1 inhibiting moiety;
• and
• L1 is a linker comprising at least one first complimentary functional group to covalently link to a functional group in A and at least one second complimentary functional group to covalently link to a functional group in B, to form the conjugate of Formula (I),
• wherein the compound of Formula I optionally comprises one or more atoms that are isotopic variants.