Drug linker and linker-conjugated compound
AssigneeAnti-Microbial Savior BioteQ Co., Ltd.
InventorsYi-Ju Tsai, Guo-Rong Luo, Ying-Ting Yeh
Life of this patent
Estimating the term…
Abstract
The present invention provides a drug linker and a linker-conjugated compound. The drug linker may provide an appropriate space, a flexible synthesis site, and a carboxylic acid moiety, and may be used to connect multiple pharmacophores to enhance biological efficacy and drug similarity, and the linker-conjugated compound has good water solubility.
Claims3
A drug linker, characterized in that it has a chemical structure represented by the following formula (1):
- wherein in formula (1),
- n is an integer from 1 to 10,
- X, Y, and Z are each independently halogen, carbon, oxygen, sulfur, NR5, or SiR5R6,
- R1 is hydrogen, C(═O)R5, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C5-10 aryl, substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C5-10 heteroaryl, substituted or unsubstituted C5-10 lactone, substituted or unsubstituted cyclohexenone, substituted or unsubstituted quinone derivatives, or together with nitrogen forms a substituted or unsubstituted heterocyclic ring having one or more heteroatoms selected from N, O and S,
- R2 is hydrogen, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C5-10 aryl, substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C5-10 heteroaryl, substituted or unsubstituted C5-10 lactone, or together with nitrogen forms a substituted or unsubstituted heterocyclic ring having one or more heteroatoms selected from N, O and S,
- R3, R5, and R6 are each independently hydrogen, substituted or unsubstituted C1-8 alkyl, or substituted or unsubstituted C5-10 aryl, and
- R4 is hydrogen, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C5-10 aryl, substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C5-10 heteroaryl, substituted or unsubstituted C5-10 lactone, or together with nitrogen forms a substituted or unsubstituted heterocyclic ring having one or more heteroatoms selected from N, O and S.
A linker-conjugated compound, characterized in that it has a chemical structure represented by the following formula (1-1):
- wherein
- R2 is hydrogen, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C5-10 aryl, substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C5-10 heteroaryl, substituted or unsubstituted C5-10 lactone, or together with nitrogen forms a substituted or unsubstituted heterocyclic ring having one or more heteroatoms selected from N, O and S, and
- R4 is hydrogen, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C5-10 aryl, substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C5-10 heteroaryl, substituted or unsubstituted C5-10 lactone, or together with nitrogen forms a substituted or unsubstituted heterocyclic ring having one or more heteroatoms selected from N, O and S.
A linker-conjugated compound, characterized in that it has a chemical structure represented by any one of the following formula (1-2) to formula (1-8):
Dependencies are inferred from the claim text.