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AssigneeJanssen Pharmaceuticals, Inc.
InventorsHelen Heide, Erika THOMAS, Marc Sylvain NOVERRAZ, Denis Louis Raymond BASCOUL, Katharina Christin BAUER, Eric Nicolaas KLIJN, Piergiuseppe NESTOLA, Leonor MONTEIRO TEIXEIRA PRATA, Martin Maximilian SCHEIDT, Renzo DANUSER, Caspar Ludwig Hermann SCHÄFER
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The present invention relates to improved pharmaceutical compositions comprising one or more bioconjugate compositions. Each bioconjugate composition comprises a mixture of mono-glycosylated and multi-glycosylated bioconjugates of specific E. coli O-antigen polysaccharide covalently coupled to a Pseudomonas aeruginosa Exoprotein A carrier protein. The invention further relates to a process for the production of purified bioconjugates from Gram-negative host cells and to bioconjugates obtained or obtainable by said process.
A pharmaceutical composition comprising one or more bioconjugate compositions,
A process for production of a purified bioconjugate from Gram-negative bacterial host cells wherein the bioconjugate comprises a bacterial O-antigen polysaccharide covalently coupled to a Pseudomonas aeruginosa ExoProtein A carrier protein (O-EPA), the process comprising:
Dependencies are inferred from the claim text.