System For Modulating Receptor Tyrosine Kinase Signaling And Methods Of Use Thereof

Abstract

Provided herein is an engineered controllable membrane targeting system based on triggered exposure of a cryptic acylation signal, a calcium-regulated protease that can be used to expose this cryptic acylation signal, a means of coupling transmembrane receptor signaling events to the activation of target acylation through this and other protease-dependent systems, and methods of use thereof. The use of this system recruits signal modulators to the plasma/endosomal membranes in response to transmembrane signaling events. The system includes an expression vector including a pro-effector protein module and a protease module. The system can be used for modulating a receptor tyrosine kinase (RTK) signaling, and for treating a subject having chronic pain, diabetes, an inflammatory disorder, cancer, or disease caused by hyperactive cell signaling pathway.

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