Platelet-binding proteins and conjugates thereof, particles comprising them and uses thereof
AssigneeHaima Therapeutics, LLC
InventorsChrista Pawlowski, Michael Bruckman, Andrew Ditto, Noah Duffy
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Abstract
The present application relates to platelet binding peptides and their conjugates, as well as particles comprising these and other peptides and conjugates. In addition, compositions and methods for using these peptides and particles are provided.
Claims122
A particle comprising a plurality of platelet binding peptide (PBP) conjugates, von Willebrand factor-binding peptide (VBP) conjugates, or collagen-binding peptide (CBP) conjugates, or a combination thereof, wherein the PBP conjugate is a fibrinogen mimetic peptide (FMP) conjugate or a P-selectin binding peptide conjugate, and wherein the plurality of PBP conjugates, VBP conjugates, and/or CBP conjugates are conjugated to an outer surface of the particle, wherein the PBP conjugates, VBP conjugates, and CBP conjugates, taken together, are present at <5 molar percent of the particle.
A fibrinogen mimetic peptide (FMP) of Formula (I):
- or a salt thereof.
Dependencies are inferred from the claim text.