Nitrogen-containing heterocyclic derivative inhibitor, and preparation method therefor and use thereof

A compound as represented by general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof:

• wherein
• ring A is selected from
• ring B is selected from C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-14 aryl, or 5- to 14-membered heteroaryl;
• L1 is selected from a bond, —(CH2)n—, —(CH2)nC(O)(CRaaRbb)n1—, —(CH2)nC(O)NRaa(CH2)n1—, —(CH2)n(CRaaRbb)n2—, —(CRaaRbb)nO(CH2)n1—, —(CH2)nO(CRaaRbb)n1—, —(CRaaRbb)n3S(CH2)n4—, —(CH2)nS(CRaaRbb)n3—, —(CRaaRbb)n3(CH2)nNRcc, —(CH2)nNRaa(CRbbRcc)n—, —(CH2)nNRaaC(O)—, —(CH2)nP(O)pRaa—, —(CH2)nS(O)m—, —(CH2)nC(O)NRaaRbb—, —(CH2)nNRccC(O)Rdd—, —(CH2)nS(O)mNRaaRbb—, and —(CH2)nNRccS(O)mRdd—;
• Raa, Rbb, Rcc and Rdd are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent substituents are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl can be optionally further substituted;
• Ra is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, alkylthio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)nRA1, —(CH2)nORA1, —(CH2)nC(O)RA1, —(CH2)nC(O)ORA1, —(CH2)nS(O)mRA1, —(CH2)nNRA2RA3, —(CH2)nNRA2C(O)ORA3, —(CH2)nNRA2C(O)(CH2)n1RA3, —(CH2)nNRA2C(O)NRA2RA3, —(CH2)nC(O)NRA2(CH2)n1RA3, —OC(RA1RA2)n(CH2)n11RA3, or —(CH2)nNRA2S(O)mRA3, wherein the amino, alkyl, alkenyl, alkynyl, alkylthio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• RA1-RA3 are each independently selected from hydrogen, deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent Ra are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• Rb is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)nRB1, —(CH2)nORB1, —(CH2)nC(O) RB1, —(CH2)nC(O)O RB1, —(CH2)nS(O)m RB1, —(CH2)nNRB2RB3, —(CH2)nNRB2C(O)ORB3, —(CH2)nNRB2C(O)(CH2)n1RB3, —(CH2)nNRB2C(O)NRB2RB3, —(CH2)nC(O)NRB2(CH2)n1RB3, —OC(RB1RB2)n(CH2)n1RB3, or —(CH2)nNRB2S(O)mRB3, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• RB1-RB3 are each independently selected from hydrogen, deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent Rb are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• Rc is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)nRC1, —(CH2)nORC1, —(CH2)nC(O)RC1, —(CH2)nC(O)O RC1, —(CH2)nS(O)m RC1, —(CH2)nNRC2RC3, —(CH2)nNRC2C(O)ORC3, —(CH2)nNRC2C(O)(CH2)n1RC3, —(CH2)nNRC2C(O)NRC2RC3, —(CH2)nC(O)NRC2(CH2)n1RC3, —OC(RC1RC2)n(CH2)n1RC3, or —(CH2)nNRC2S(O)mRC3, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• RC1-RC3 are each independently selected from hydrogen, deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent Rc are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• Rd is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)nRD1, —(CH2)nORD1, —(CH2)nC(O) RD1, —(CH2)nC(O)O RD1, —(CH2)nS(O)m RD1, —(CH2)nNRD2RD3, —(CH2)nNRD2C(O)ORD3, —(CH2)nNRD2C(O)(CH2)n1RD3, —(CH2)nNRD2C(O)NRD2RD3, —(CH2)nC(O)NRD2(CH2)n1RD3, —OC(RD1RD2)n(CH2)n1RD3, or —(CH2)nNRD2S(O)mRD3, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• RD1-RD3 are each independently selected from hydrogen, deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent Rd are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two Rc and Rd are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• x is 0, 1, 2, or 3;
• y is 0, 1, 2, or 3;
• z is 0, 1, 2, or 3;
• e is 0, 1, 2, or 3;
• m is 0, 1, or 2;
• n is 0, 1, 2, 3, or 4;
• n1 is 0, 1, 2, 3, or 4;
• n2 is 0, 1, 2, 3, or 4;
• n3 is 0, 1, 2, 3, or 4;
• and
• n4 is 0, 1, 2, 3, or 4.