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US 2026/0193172 A1Published application
Cycloalkane-based lipid compound for delivering nucleic acids, and lipid nanoparticles comprising same
AssigneeThe Green Cross Corporation
InventorsYizhou DONG, Yuebao ZHANG, Diana Daeun KANG, Shi DU
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Abstract
A cycloalkane-based lipid compound of Formula 1 and a pharmaceutically acceptable salt thereof are disclosed. The cycloalkane-based lipid compound is a compound having a form in which carbonyl-based substituents are bonded to the central structure of a cycloalkane. The cycloalkane-based lipid compound is used as an ionizable lipid, which is a component of a lipid nanoparticle for delivering a nucleic acid.
Claims9
A cycloalkane-based lipid compound of Formula 1 below and a pharmaceutically acceptable salt thereof:
- wherein:
- n1 is 1 to 4;
- n2 is 1 to 4;
- when n2 is 2 or 3, each of the substituents linked to a cycloalkane is independent;
- AK1 is alkylene having 1 to 5 carbon atoms;
- T is alkyl or alkenyl having 6 to 20 carbon atoms, or
- AK2 is alkylene having 6 to 10 carbon atoms;
- and
- AK3 is alkyl or alkenyl having 6 to 10 carbon atoms.
6 more elements
Dependencies are inferred from the claim text.