Method of preventing and/or reducing metastasis of tumor cells, preventing or reducing senescence, inhibiting differentiation and of reducing inflammation
AssigneeAlbert-Ludwigs-Universitaet
InventorsGeorg HAECKER, Aladin HAIMOVICI, Arnim WEBER
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Abstract
The present application refers to a method of preventing or reducing metastasis of tumor cells, senescence, differentiation or inflammation wherein the caspase-activated DNAse which induces strand breaks in the genomic DNA of cells causing changes of the behavior of the cell involving aggressive growth, senescence, differentiation and metastasis and/or inflammation is inactivated.
Claims15
A method for influencing the development of cells, said method comprising the step of adding to a cell an inhibitor of a caspase-activated DNAse that induces strand breaks in said cell's genomic DNA that cause changes of the behavior of the cell, whereby addition of said inhibitor inactivates said caspase-activated DNAse.
A method of identifying molecules that inhibit a caspase-activated DNAse, said method comprising the step of performing an in vitro test system in which the inactivating activity of a compound is measured by contacting said compound with the caspase-activated DNAse, further wherein said an in vitro test system comprising the preparation of extracts containing CAD-activity or a system where CAD-activity is generated by the use of recombinant components and adding thereto recombinant caspase and the compound to be tested.
Dependencies are inferred from the claim text.