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US 2026/0184820 A1Published application
Peptide conjugates of cytotoxins as therapeutics
AssigneeCybrexa 2, Inc.
InventorsDaniel Richard Marshall, Johanna Marie Csengery, Robert John Maguire, Robert A. Volkmann
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Abstract
The present invention relates to peptide conjugates of cytotoxins such as topoisomerase I inhibitors which are useful for the treatment of diseases such as cancer.
Claims11
1-50. (canceled)
A method of treating cancer in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound which is:
- or a pharmaceutically acceptable salt thereof,
- wherein Pv1 is a peptide comprising the sequence:
- ADDQNPWRAYLDLLFPTDTLLLDLLWCG (SEQ ID NO:
- 1),
- and wherein the cancer is selected from ovarian cancer, breast cancer, colorectal cancer, lung cancer, kidney cancer, Ewing's sarcoma, and solid tumors of childhood.
2 more elements
52-55. (canceled)
Dependencies are inferred from the claim text.