Cxcr3 overexpression in car-nk cells primes migration/homing into the tumor microenvironment

A nucleic acid construct comprising:

• a first nucleic acid comprising a first promotor operably linked to a nucleic acid encoding a C—X—C Motif Chemokine Receptor 3 (CXCR3);
• and
• a second nucleic acid encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a ligand binding domain comprising a single chain antibody fragment that binds an antigen on a tumor cell, a transmembrane domain, and an intracellular domain comprising a signaling domain.