System and method for ambient-light-corrected computational pupillometry

Abstract

A computational pupillometry system comprises an imaging device configured to capture video frames of a subject's eye and processors executing instructions to perform advanced pupillary assessment. The system employs multi-frame integration techniques, including super-resolution algorithms that utilize sub-pixel shifts between frames, temporal averaging for noise reduction, and parallax-based artifact mitigation to enhance measurement accuracy. Artificial intelligence models, including temporal neural networks, analyze the enhanced pupillary data to determine pupillary parameters and calculate a light-invariant Pupil Reactivity (PuRe) score. The system processes ambient lighting conditions through computational models that analyze video frames before and after controlled stimulation, enabling consistent scoring across varying environmental conditions. Quality assurance mechanisms provide pre-recording and post-recording validation with real-time feedback. The system integrates with electronic medical records through standardized healthcare protocols and supports synchronized, multi-device deployment across healthcare networks.

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