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US 2026/0176695 A1Published application
Method and kits for a transcriptomic signature with empirically derived algorithm correlated to the presence of acute rejection on kidney biopsy in transplant recipient blood
AssigneeVerici Dx Limited
InventorsPatricia CONNOLLY, Chan Ju WANG, Nehal DOSHI
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a method for a diagnostic tool to calculate a renal allograft recipient's risk for acute rejection.
Claims29
A method for identifying the risk that a renal allograft recipient is experiencing allograft rejection comprising the steps of:
- (a) isolating RNA from a biological specimen from the renal allograft recipient;
- (b) determining the expression levels of a preselected gene signature set in the specimen of the recipient;
- wherein the preselected gene set comprises the genes OSM, TSC22D1, ST8SIA1, RTN1, IFITM3, ANXA5, CAPS2, and SOCS3;
- (c) normalizing the expression levels of the preselected gene signature set;
- (d) calculating a risk score using an empirically derived algorithm from normalized expression levels of the preselected gene signature set;
- and
- (e) determining whether the recipient's risk score falls within high or low risk category for allograft rejection.
4 more elements
A method for selecting a renal allograft recipient for treatment to reduce the risk of renal allograft rejection which comprises
- (a) isolating RNA from a blood specimen from the renal allograft recipient;
- (b) determining the expression levels of a preselected gene signature set in the blood of the recipient;
- (c) normalizing the expression levels of the preselected gene signature set;
- (d) calculating a risk score using an empirically derived algorithm from normalized expression levels of the preselected gene signature set;
- (d) determining whether the recipient is at high risk or low risk for allograft rejection based on the risk score which is delivered to a clinician as an interpreted result;
- and
- (e) administering a treatment to prevent allograft rejection if the recipient is at high risk for allograft rejection,
- wherein the preselected gene set comprises the genes OSM, TSC22D1, ST8SIA1, RTN1, IFITM3, ANXA5, CAPS2, and SOCS3.
5 more elements
Dependencies are inferred from the claim text.