US 2026/0175216 A1 · SYSTEMS COMPRISING A MICROFLUIDIC DEVICE AND METHODS FOR OBTAINING A SIGNAL

Abstract

A system including a microfluidic device with a substrate, a non-hyperpolarized isotope label to be introduced, and an apparatus. The substrate of the microfluidic device includes one or more inlet channels, a sample matrix including an analyte, a measuring chamber, and an outlet channel. The non-hyperpolarized isotope label is introduced in an inlet channel so that the non-hyperpolarized isotope label is contacted with the analyte of the sample matrix to form a detection complex. The apparatus obtains a signal of the detection complex. A method of obtaining a signal of the detection complex using a sample matrix is provided.

Claims15

Dependent claims

A system comprising:

a microfluidic device with a substrate comprising:
one or more inlet channels;
a sample matrix comprising an analyte;
a measuring chamber, the one or more inlet channels being fluidically connected to the measuring chamber, the measuring chamber being configured to receive the sample matrix comprising the analyte;
and
an outlet channel fluidically connected to the measuring chamber;
a non-hyperpolarized isotope label to be introduced in the measuring chamber through one of the one or more inlet channels so that the non-hyperpolarized isotope label is contacted with the analyte of the sample matrix to form a detection complex;
and
an apparatus to obtain a signal of the detection complex.

6 more elements

A method for obtaining a signal of a detection complex using a sample matrix, the method comprising:

providing a microfluidic device with a substrate comprising:
one or more inlet channels;
the sample matrix comprising an analyte;
a measuring chamber, the one or more inlet channels being fluidically connected to the measuring chamber, the measuring chamber being configured to receive the sample matrix comprising the analyte;
and
an outlet channel fluidically connected to the measuring chamber;
introducing a non-hyperpolarized isotope label in the measuring chamber through one of the one or more inlet channels so that the non-hyperpolarized isotope label is contacted with the analyte of the sample matrix to form a detection complex.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/124,792Filed 26 Oct 2023

Priority

EP 22383034.026 Oct 2022

Published

25 Jun 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

B01L 3/502715
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
G01R 33/465
NMR spectroscopy: applied to biological material, e.g. in vitro testing
B01L 3/5027
With fluid transport, e.g. in multi-compartment structures: by integrated microfluidic structures, i.e. dimensions of channels and chambers are…
B01L 3/502753
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…

Systems comprising a microfluidic device and methods for obtaining a signal

Life of this patent

Systems comprising a microfluidic device and methods for obtaining a signal

Life of this patent

Abstract

Claims15