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US 2026/0174861 A1Published application
Expansion of gamma delta t cells, compositions, and methods of use thereof
AssigneesKing's College London, GammaDelta Therapeutics Ltd
InventorsRichard BEATSON, Adrian HAYDAY, Oliver NUSSBAUMER, Richard WOOLF, Maria Luisa IANNITTO, Natalie MOUNT
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Abstract
The present invention provides methods of expanding γδ T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded γδ T cells and methods of using the expanded γδ T cells (e.g., a part of an adoptive T cell therapy).
Claims22
1-60. (canceled)
An isolated population of skin-derived γδ T cells,
- wherein the γδ T cells are cultured in the presence of:
- (a) IL-2 or IL-9;
- (b) IL-15;
- and
- (c) IL-21
- for at least 5 days in amounts effective to produce an expanded population of γδ T cells;
- and
- wherein at least 50% of γδ T cells of the isolated population express CD27 and Vδ1, and do not substantially express TIGIT.
5 more elements
(canceled)
64-65. (canceled)
Dependencies are inferred from the claim text.