Biomimetic chip, method for manufacturing same, and method for coating extracellular matrix by using same

Abstract

Provided is a microphysiological system including a substrate having a first groove, a cover part disposed opposite the substrate and having a second groove formed on a surface thereof facing the substrate, a porous membrane disposed between the substrate and the cover part so as to have an area overlapping at least the first groove and the second groove, and a plurality of openings having a first inlet, a first outlet, a second inlet, and a second outlet, which pass through the cover part in a thickness direction or in a direction perpendicular to the thickness direction. The microphysiological system maintains a constant circulation velocity of fluid within a microfluidic channel to induce uniform-density adhesion of cells on the surface of the microfluidic channel during cell culture and circulation, and is bonded by using oxygen plasma and a silane coupling agent and thus attached immediately and strongly through chemical bonding.

Dependencies are inferred from the claim text.