Bismuth-thiol compositions and methods for treating inflammatory diseases
AssigneeMicrobion Corporation
InventorBrett Hugh James BAKER
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Abstract
The present disclosure relates to pravibismane compositions and their use in methods for treating inflammation-related diseases or conditions, such as an inflammatory disease of the lung, psoriasis, and acne vulgaris in a subject. Treatment of inflammation-related diseases and conditions according to the disclosed methods provides an increase in the expression of anti-inflammatory cytokines, including IL-10, and/or a decrease in the expression of one or more pro-inflammatory cytokines, such as one or more of IFN-γ, MIP-3a, MIP-1β, TNF-a, IL-22, IL-17A, IL-15, and IL-13.
Claims66
A method of treating an inflammation-related and/or fibrotic disease or condition in a subject in need thereof, comprising administering to the subject an effective amount of a bismuth-thiol (BT) composition comprising pravibismane, wherein the effective amount is effective in the subject to exert an anti-inflammatory effect by therapeutically:
- modulating IL-10 levels;
- and/or,
- modulating TNF-α levels;
- and/or,
- inhibiting neutrophil-mediated inflammation/transmigration/infiltration;
- and/or,
- inhibiting excessive or exuberant or pathological fibrosis.
The method of any one of the preceding claims, wherein pravibismane is provided in a composition that further comprises about 0.05% to about 1.0% polysorbate 80, optionally about 0.05 to 40 mM sodium chloride, optionally about 1% to about 10% of methylcellulose, and optionally about 2 to 20 mM sodium phosphate at about pH 7.4.
The method of any one of the preceding claims, wherein the pravibismane is administered three times per day, two times per day, once daily, every other day, once every three days, three times per week, once every week, once every other week, once every month, or once every other month.
The method of any one of the preceding claims, wherein the pravibismane is administered topically or by inhalation.
The method of any one of the preceding claims, wherein the pravibismane is administered orally or systemically.
Dependencies are inferred from the claim text.