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OwnerYue-Ming Li, Wan Fung Eitan Wong +4inventors
InventorsYue-Ming Li, Wan Fung Eitan Wong, Manish Malviya, David A. Scheinberg, Kristen Vogt, George Liao
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The present disclosure provides methods for preventing or treating Alzheimer's disease in a subject, and/or reducing the likelihood or severity of Alzheimer's disease comprising administering to the subject an effective amount of an anti-CD33 antibody or an antigen binding fragment thereof. Alternatively, the methods comprise administering to the subject an effective amount of engineered immune cells expressing a neuronal antigen specific CAR and an anti-CD33 antibody or an antigen binding fragment thereof.
A method for treating or preventing Alzheimer's disease or reducing brain accumulation and/or persistence of AP plaques in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-CD33 antibody, or an antigen binding fragment thereof, wherein the anti-CD33 antibody or antigen binding fragment includes an immunoglobulin heavy chain variable region (VH) comprising SEQ ID NO:
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An engineered immune cell comprising:
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A mixture of polypeptides comprising a first polypeptide comprising FoxP3 and a chimeric antigen receptor that specifically binds to a neuronal antigen, and a second polypeptide comprising an anti-CD33 antibody, or an antigen binding fragment thereof, wherein the anti-CD33 antibody or antigen binding fragment includes an immunoglobulin heavy chain variable region (VH) comprising SEQ ID NO:
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Dependencies are inferred from the claim text.