Compositions and methods for the treatment of hemorrhagic shock
AssigneeChildren's Hospital Medical Center
InventorBasilia Zingarelli
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Abstract
Disclosed are methods of treating hemorrhagic shock, for example hemorrhagic shock associated with traumatic injury, gastrointestinal bleeding, spontaneous hemorrhage due to hematologic disorders, uterine hemorrhage, and combinations thereof, in an individual in need thereof. The methods may comprise administering a humanin protein or an analog thereof, for example Humanin G, to the individual.
Claims28
A method of treating hemorrhagic shock in an individual in need thereof, comprising administering a humanin protein or an analog thereof to said individual.
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A method of treating an individual for hemorrhagic shock, comprising
- a. detecting a biomarker selected from IL-6, IL-10, KC, TNFα, and combinations thereof, and
- b. treating said individual having an elevation of said biomarker with humanin protein or an analog thereof to said individual.
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A method for monitoring the progression, severity, and or likelihood of progressing to multiple organ dysfunction syndrome (MODS), comprising detecting serum or blood levels of humanin in an individual at risk for multiple organ dysfunction syndrome.
Dependencies are inferred from the claim text.