Biodegradable fuse-and-reservoir system for the pulsed delivery of bioactive agents

Abstract

Disclosed herein is a device for delivering one or more bioactive agents, the device comprising a first layer comprising a first biodegradable polymer, wherein the first layer has a first and a second side, and wherein a plurality of reservoirs comprising one or more bioactive agents are present on the first side; a second layer comprising a second biodegradable polymer, wherein the second layer is adjacent to the first side of the first layer; and a third layer comprising a third biodegradable polymer, wherein the third layer encapsulates the first and second layers, and wherein at least one face of the device comprises an exposed second layer not coated by the third biodegradable polymer. In one aspect, the first and third biodegradable polymers are poly-ε-caprolactone, while the second biodegradable polymer is a mixture of cellulose acetate phthalate and a poloxamer. Also disclosed are methods for fabricating the devices.

Dependencies are inferred from the claim text.