Method of modifying cells
OwnerLeslie YEO, Lizebona August AMBATTUinventors
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Abstract
Provided are methods and associated apparatus for increasing calcium mobilisation in a cell. Calcium mobilisation is through exposing the cells to acoustic wave energy such as through surface acoustic waves (SAW) and surface reflected bulk waves (SRBW). Included are methods of treating immune cells to activate the immune cells, increase cytokine production and differentiate monocytes to macrophages. Also included are methods involving exposing ova and/or sperm to acoustic wave energy for in vitro fertilisation and/or artificial insemination.
Claims41
A method of increasing calcium mobilisation in a cell comprising exposing the cell to acoustic wave energy.
A method of fertilising an ovum, the method comprising
- 1) exposing the ovum to acoustic wave energy, and
- 2) fertilising the ovum with a sperm;
- or
- 1) exposing sperm to acoustic wave energy, and
- 2) fertilising the ovum with the sperm.
A method of activating an immune cell, the method comprising exposing the immune cell to acoustic wave energy.
A method of increasing cytokine production of an immune cell, the method comprising activating the immune cell by exposing the immune cell to acoustic wave energy.
A method of artificial insemination, the method comprising exposing sperm to acoustic wave energy, and implanting the sperm into the reproductive tract of a female subject.
A method of differentiating a monocyte into a macrophage, the method comprising exposing the monocyte to acoustic wave energy.
Dependencies are inferred from the claim text.