ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF BINDING TO ß-CTx AND KIT THEREOF

An antibody or an antigen-binding fragment thereof capable of binding to 3-CTx, comprising:

• a heavy chain variable region (VH) and a light chain variable region (VL),
• wherein the heavy chain variable region comprises HCDR1 having an amino acid sequence as set forth in any one of SEQ ID NO:
• 1, 7, 13, 19, 25, 31, 37, 43, 49 or 55 or a variant thereof, HCDR2 having an amino acid sequence as set forth in any one of SEQ ID NO:
• 2, 8, 14, 20, 26, 32, 38, 44, 50 or 56 or a variant thereof, and HCDR3 having an amino acid sequence as set forth in any one of SEQ ID NO:
• 3, 9, 15, 21, 27, 33, 39, 45, 51 or 57 or a variant thereof,
• wherein, the light chain variable region comprises LCDR1 having an amino acid sequence as set forth in any one of SEQ ID NO:
• 4, 10, 16, 22, 28, 34, 40, 46, 52 or 58 or a variant thereof, LCDR2 having an amino acid sequence as set forth in any one of SEQ ID NO:
• 5, 11, 17, 23, 29, 35, 41, 47, 53 or 59 or a variant thereof, and LCDR3 having an amino acid sequence as set forth in any one of SEQ ID NO:
• 6, 12, 18, 24, 30, 36, 42, 48, 54 or 60 or a variant thereof, and
• wherein each variant comprises one or more amino acid mutations compared to the amino acid sequence from which it is derived, and each amino acid mutation is selected from amino acid substitution, deletion or addition;
• preferably, the substitution is a conservative substitution;
• preferably, each variant has at least 80%, at least 90%, or at least 95% identity to the amino acid sequence from which it is derived.