Radiolabeled amino acids for cancer imaging, therapy and corresponding labeling methods thereof

A compound of Formula (I):

• wherein:
• X is —O—, —NH—, —N[(C3-C6) cycloalkyl]-, or —N[(C1-C6) alkyl]-;
• R1 and R2 are independently selected from the group consisting of —H, -PG, —CH2Ar, —(C1-C4) alkyl, and —(C3-C7) cycloalkyl;
• or X and R1 together form a (C3-C5) heterocycle;
• R3 is a radioisotope R* selected from the group consisting of [210]At and [211]At, wherein R3 is in the 2-position on the phenyl ring;
• R4 is —F, or radioisotope [18]F;
• R5 is -PG, —(C1-C6) alkyl, or —(C3-C6) cycloalkyl;
• R6 and R7 are independently selected from the group consisting of —H, -PG, —CH2Ar, —(C1-C4) alkyl, and —(C3-C6) cycloalkyl;
• or R6 and R7 together form a (C3-C5) heterocycle;
• PG, in each instance, is a protecting group;
• m is 1, 2, or 3;
• and
• n is 0, 1, or 2;
• or any stereoisomer and/or pharmaceutically acceptable salt thereof.