Back to results
US 2026/0158174 A1Published application
Molecular renal probes for detecting acute kidney injury
AssigneeNanyang Technological University
InventorsKanyi Pu, Jiaguo Huang
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compounds or salts and/or solvates of formula I, II and Ill, where the compounds or salts and/or solvates have the following structures: where X, Y, Z, X′, Y′, a, b, R4, R6 and R7 are as defined herein.
Claims20
A compound of formula I:
- where:
- X is selected from:
- where R1 represents a biomarker reactive moiety or a biomarker reactive moiety conjugated to a self-immolative moiety
- R2 represents a point of attachment to Y and R2 represents another point of attachment to the same
- Y group or a point of attachment to a second Y group;
- R3 represents H, SO3H or COOH;
- Z is selected from:
- R4 is selected from:
- where the wavy line represents the point of attachment to the rest of the molecule;
- R4′ represents the point of attachment to Y:
- each Y is selected from:
- (1≤m≤50, 10≤n≤500) where the wavy line represents the point of attachment to X or Z,
- (1≤m≤50, 10≤n≤500) where the wavy line represents the point of attachment to X or Z,
- where each R5 is independently selected from H, CH2CHOHCH3, CH2CCH, and
- where the left-hand wavy line (adjacent to m) represents the point of attachment to X or Z and the right-hand wavy line represents the point of attachment to the rest of the molecule;
- a is 0 or 1 and b is 0 or 1, provided that:
- at least one of a and b is 1;
- and
- when a and b are both 1, Y is selected from:
- or pharmaceutically acceptable salts and/or solvates thereof, provided that when X is
- then Z is 0.
18 more elements
A compound according to formula II:
- where:
- R4 is selected from:
- H
- where the wavy line represents the point of attachment to the rest of the molecule;
- R6 is OH or OC1-C6 alkyl;
- R7 is:
- or pharmaceutically acceptable salts and/or solvates thereof.
4 more elements
A compound of formula 11:
- where:
- X′ is selected from:
- where R1 represents a biomarker reactive moiety or a biomarker reactive moiety conjugated to a self-immolative moiety
- one R2 represents the point of attachment to Y′ and the other R2 represents Y″;
- R3 represents H, SO3H or COOH;
- Y′ and Y″ are selected from H, CmH2m+1 (1≤m≤50),
- the wavy line represents the point of attachment to X′, or pharmaceutically acceptable salts and/or solvates thereof.
4 more elements
Dependencies are inferred from the claim text.