Polyphenol lipid nanoparticles and methods of use
AssigneeThe University of North Carolina at Chapel Hill
InventorsOwen Fenton, Yutian Ma
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Abstract
Disclosed herein are polyphenol lipid nanoparticles, including about 5-95 mol % ionizable lipid, about 5-30 mol % phospholipid, about 30-60 mol % sterol, about 1-5 mol % PEG lipid, and about 0.5-15 mol % polyphenol. Methods of making the lipid nanoparticles comprising a cargo, and methods of delivering a lipid nanoparticle comprising a cargo are provided. Methods of increasing endosomal escape of a lipid nanoparticle delivered to a cell are also provided and comprise inclusion of polyphenol in the lipid nanoparticle.
Claims27
A polyphenol lipid nanoparticle (LNP), comprising about 5-95 mol % ionizable lipid, about 5-30 mol % phospholipid, about 30-60 mol % sterol, about 1-5 mol % PEG lipid, and about 0.5-15 mol % polyphenol.
The polyphenol LNP, wherein the polyphenol is a flavonoid or a non-flavonoid.
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A method of making a cargo-loaded nanoparticle comprising:
- adding an organic phase comprising a polyphenol, a sterol, a PEG lipid, an ionizable lipid and a phospholipid to an aqueous phase comprising a cargo to make a mixture.
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Dependencies are inferred from the claim text.