Herpesviral combination therapy for targeting cancer cells and cancer associated stromal cells
AssigneeMayo Foundation for Medical Education and Research
InventorsHaifei Jiang, Stephen James Russell
Life of this patent
Estimating the term…
Abstract
Methods and materials for targeting cancer cells and cancer-associated stromal cells within a tumor are provided herein. For example, this document provides compositions that contain recombinant herpesviruses from two or more different sub-families, and also provides methods for using such compositions to treat mammals having cancer.
Claims25
A composition comprising a first recombinant human herpesvirus and a second recombinant human herpesvirus, wherein said first and second recombinant human herpesviruses are from two different herpesvirus sub-families, and wherein, when said composition is administered to a mammal having cancer, said first recombinant human herpesvirus infects a cancer cell and said second recombinant human herpesvirus infects a stromal cell associated with said cancer, thereby reducing the number of cancer cells within said mammal.
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A method for treating a mammal having cancer, wherein said method comprises administering, to said mammal, a composition of comprising a first recombinant human herpesvirus and a second recombinant human herpesvirus, wherein said first and second recombinant human herpesviruses are from two different herpesvirus sub-families, and wherein, when said composition is administered to said mammal having cancer, said first recombinant human herpesvirus infects a cancer cell and said second recombinant human herpesvirus infects a stromal cell associated with said cancer, thereby reducing the number of cancer cells within said mammal.
A method for treating a mammal having cancer, wherein said method comprises:
- (a) administering, to said mammal, a first recombinant human herpesvirus, and
- (b) administering, to said mammal, a second recombinant human herpesvirus,
- wherein said first and second recombinant human herpesviruses are from two different herpesvirus sub-families, and wherein said first recombinant human herpesvirus infects a cancer cell of said mammal and said second recombinant human herpesvirus infects a stromal cell associated with said cancer, thereby reducing the number of cancer cells within said mammal.
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Dependencies are inferred from the claim text.