Vector for expression of chimeric antigen receptor and uses thereof
AssigneeGenVivo, Inc.
InventorsAlexander T. CUNHA, Makoto SATO, Cecilia S. ROH, Robert G. JOHNSON, JR.
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Abstract
The engineered viral vectors provided herein may comprise a modified envelope protein. In some aspects, the modified envelope protein comprises a targeting moiety. The engineered viral vectors provided herein may comprise a first payload vector encoding a chimeric antigen receptor (CAR). The engineered viral vectors may further comprise other modifications.
Claims21
-48. (canceled)
A method of expressing a chimeric antigen receptor (CAR) in a cell of a subject comprising contacting the cell of the subject with an engineered viral vector comprising a first payload vector encoding a chimeric antigen receptor (CAR), under conditions suitable to express the CAR in the cell of the subject.
A method of treating or preventing a disease or condition in a subject comprising administering to the subject an engineered viral vector comprising a first payload vector encoding a chimeric antigen receptor (CAR), wherein expression of the CAR affects the disease or condition in the subject.
Dependencies are inferred from the claim text.