Loading patent…
AssigneeVirginia Tech Intellectual Properties, Inc.
InventorsBrandon L. Jutras, Christine JACOBS-WAGNER
Estimating the term…
The present disclosure relates to a method of diagnosing Lyme disease in a subject comprising measuring the level of B. burgdorferi peptidoglycan or the level of an antibody that specifically binds to B. burgdorferi peptidoglycan (“anti-peptidoglycan agent”). The present disclosure also relates to a method of treating a Lyme disease in a subject in need thereof comprising administering to the subject an antagonist against B. burgdorferi peptidoglycan (e.g., an anti-peptidoglycan antibody or a peptidoglycan-specific hydrolase). Antagonists (e.g., anti-peptidoglycan antibodies) suitable for the present methods are also disclosed.
A method of diagnosing Lyme disease in a subject in need thereof comprising contacting an antibody or innate immunity protein that specifically binds to Borrelia burgdorferi peptidoglycan (“anti-peptidoglycan agent”) with a biological sample of the subject and measuring the level of Borrelia burgdorferi peptidoglycan in the sample.
A method of diagnosing Lyme disease in a subject in need thereof comprising contacting an anti-idiotypic antibody with a biological sample of the subject and measuring the level of the anti-idiotypic antibody in the sample, wherein the anti-idiotypic antibody binds to a region of an antibody that specifically binds to B. burgdorferi peptidoglycan.
Dependencies are inferred from the claim text.