Pharmaceutical composition for preventing and treating geriatric diseases comprising neural stem cells derived from three-dimensional hypothalamus organoid and use thereof

Abstract

The present invention relates to a pharmaceutical composition for preventing and treating geriatric diseases, comprising hypothalamus-like organoid-derived neural stem cells as an active ingredient. It was found that decreased memory, cognitive ability, muscle strength, muscle tissue density, and bone mineral density in aging mice due to aging were restored when the hypothalamus-like organoid-derived neural stem cells according to the present invention were transplanted into the aging mice. In addition, the transplantation of the hypothalamus-like organoid-derived neural stem cells was found to improve obesity by increasing energy metabolism. It was found that decreased memory, cognitive ability, and muscle strength in aging mice were similarly restored when exosomes isolated from the hypothalamus-like organoid-derived neural stem cells were transplanted into the aging mice. Therefore, the hypothalamus-like organoid-derived neural stem cells according to the present invention are expected to be very useful as an agent for preventing and treating geriatric diseases.

Dependencies are inferred from the claim text.