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US 2026/0151409 A1Published application
Methods and compositions for substituted axially-chiral cannabinol analogs
OwnerAlexander James Grenning, Primali Vasundera Navaratneinventors
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Abstract
In one aspect, the disclosure relates to substituted axially-chiral cannabinol analogs, methods of making same, pharmaceutical compositions comprising same, and methods of treating pain using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Claims20
A method for the treatment of a disorder in a mammal, comprising the step of administering to the mammal a therapeutically effective amount of at least one compound represented by a formula:
- wherein R1 is selected from hydrogen, halo, cyano, amino, hydroxyl, methoxy, acetoxy, —OC6H5, and —OCH2C6H5, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted —(C0-C12 alkyl)-aryl, optionally substituted —(C0-C12 alkyl)-heteroaryl, optionally substituted —(C0-C12 alkyl)-cycloalkyl, and optionally substituted —(C0-C12 alkyl)-heterocycloalkyl;
- wherein each of R2, R4, R6a, and R6b is independently selected from hydrogen and C1-C6 alkyl;
- wherein R3 is selected from hydrogen, halo, cyano, amino, hydroxyl, optionally substituted C1-C12 alkyl, optionally substituted alkenyl, optionally substituted C1-C12 alkynyl, optionally substituted —(C0-C12 alkyl)-aryl, optionally substituted —(C0-C12 alkyl)-heteroaryl, optionally substituted —(C0-C12 alkyl)-cycloalkyl, and optionally substituted —(C0-C12 alkyl)-heterocycloalkyl;
- wherein each of R7, R8, and R9 is independently selected from hydrogen, halo, cyano, amino, hydroxyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted —(C0-12 alkyl)-aryl, optionally substituted —(C0-C12 alkyl)-heteroaryl, optionally substituted —(C0-C12 alkyl)-cycloalkyl, and optionally substituted —(C0-C12 alkyl)-heterocycloalkyl;
- and
- wherein R10 is selected from hydrogen, halo, cyano, amino, hydroxyl, —CH2OH, —CH2OAc, —CH2NH2, —CH2X, —C(O)H, —C(O)NR21aR21b, —C(O)OR20, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted —(C0-12 alkyl)-aryl, optionally substituted —(C0-C12 alkyl)-heteroaryl, optionally substituted —(C0-C12 alkyl)-cycloalkyl, and optionally substituted —(C0-C12 alkyl)-heterocycloalkyl,
- wherein X is halogen;
- wherein R20 is selected from hydrogen and C1-C6 alkyl;
- wherein each of R21a and R21b is selected from hydrogen and C1-C6 alkyl;
- or a pharmaceutically acceptable salt of the same, or a pharmaceutical composition comprising the same.
7 more elements
Dependencies are inferred from the claim text.