Use of Tetramethylpyrazine Nitrone Derivatives In The Treatment of Ischemic Stroke

Abstract

The present invention provides the use of tetramethylpyrazine nitrone derivatives in the treatment of ischemic stroke, including administration of a therapeutically effective amount of tetramethylpyrazine nitrone derivatives or pharmaceutical compositions thereof. In clinical experiments, it was unexpectedly found that the combination of TBN+t-PA significantly improved the NIHSS scores of neurological function in patients on the 30th and 90th days. In addition, the combination of TBN+t-PA significantly improved the neurological function mRS score of patients, and the complete cure rate (mRS score of 0) was significantly higher than that of the t-PA group.

Dependencies are inferred from the claim text.