Gastroretentive systems and methods of making and using same

A gastroretentive system comprising:

• a dissolvable outer capsule;
• a body disposed within the outer capsule;
• and
• a plurality of springs coupled to the body, each of the plurality of springs having a compressed condition when disposed within the outer capsule and a relaxed condition when removed from the outer capsule, the plurality of springs, in relaxed conditions, being configured and arranged to prevent the body from passing through a human pylorus, wherein at least one of the body and plurality of springs comprises a drug product.

A method of delivering a drug product, comprising:

• providing a gastroretentive system including a dissolvable outer capsule, a body disposed within the outer capsule, and a plurality of springs coupled to the body, each of the plurality of springs having a compressed condition when disposed within the outer capsule and a relaxed condition when removed from the outer capsule, wherein at least one of the body and plurality of springs comprises a drug product;
• swallowing the outer capsule;
• dissolving the outer capsule;
• and
• permitting the plurality of springs to transition to relaxed conditions to impede passage of the body through a human pylorus.