Methods for modulating regulatory t cells
AssigneeUniversite de Lausanne
InventorsPing-Chih Ho, Haiping Wang
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Abstract
This disclosure describes a novel approach that specifically modulates the activity and/or the number of intratumoral regulatory T (Treg) cells in a subject. Such an approach can be used to reduce the number of intratumoral T regulatory cells in a subject as well as to inhibit tumor growth in a subject having a cancer without eliciting autoimmune responses.
Claims33
A method of reducing the number of intratumoral T regulatory cells in a subject in need thereof comprising administering to the subject an effective amount of a CD36 inhibitor.
A method of reducing the number of intratumoral T regulatory cells in a subject in need thereof comprising administering to the subject an effective amount of a PPARβ inhibitor.
A method of increasing the number of intratumoral cytotoxic T-cells in a subject in need thereof comprising administering to the subject an effective amount of a CD36 inhibitor.
A method of increasing the number of intratumoral cytotoxic T-cells in a subject in need thereof comprising administering to the subject an effective amount of a PPARβ inhibitor.
The method of any one of the preceding claims, further comprising administering to the subject an additional therapeutic agent.
The method of any one of the preceding claims, wherein the subject has cancer.
A method of inhibiting tumor growth in a subject having a cancer, comprising administering to the subject a therapeutically effective amount of a CD36 inhibitor alone or in combination with an additional therapeutic agent.
A method of inhibiting tumor growth in a subject having a cancer, comprising administering to the subject a therapeutically effective amount of a PPARβ inhibitor alone or in combination with an additional therapeutic agent.
The method of any one of claims 22 and 27 to 30, wherein the CD3 inhibitor is administered intratumorally, intravenously, subcutaneously, intraosseously, orally, transdermally, in sustained release, in controlled release, in delayed release, as a suppository, or sublingually.
Dependencies are inferred from the claim text.