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US 2026/0144904 A1Published application
Mesothelin-Binding Theranostic Fibronectin Type III Tenth Domain (Fn3) Compounds
AssigneesSmith College, University of Pisa
InventorsSarah J. Moore, Margherita Piccardi, Roberto Silvestri, Paola Anna Erba, Roberto Giovannoni, Stefano Landi, Federica Gemignani
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Abstract
Mesothelin-binding theranostic fibronectin type III (Fn3) domain polypeptides conjugated to DOTAGA are described.
Claims20
A theranostic compound comprising:
- (1) a polypeptide comprising a modified human fibronectin type III (Fn3) domain, wherein the polypeptide specifically binds to human mesothelin, and wherein BC, DE, and FG loops of the modified Fn3 domain comprise, respectively, the amino acid sequences set forth in:
- (a) SEQ ID NOs:
- 20, 23, and 25, respectively,
- (b) SEQ ID NOs:
- 20, 23, and 26, respectively,
- (c) SEQ ID NOs:
- 20, 24, and 26, respectively,
- (d) SEQ ID NOs:
- 20, 23, and 27, respectively,
- (e) SEQ ID NOs:
- 20, 23, and 28, respectively,
- (f) SEQ ID NOs:
- 20, 23, and 29, respectively,
- (g) SEQ ID NOs:
- 21, 23, and 30, respectively,
- (h) SEQ ID NOs:
- 22, 23, and 31, respectively, or
- (i) SEQ ID NOs:
- 20, 23, and 32, respectively;
- and
- (2) 1,4,7,10-tetraazacyclododececane,1-(glutaric acid)-4,7,10-triacetic acid (DOTAGA),
- wherein the DOTAGA is coupled to the polypeptide.
19 more elements
A theranostic compound comprising (1) a polypeptide comprising a modified human fibronectin type III (Fn3) domain, wherein (a) each non-loop region of the Fn3 domain comprises an amino acid sequence having at least 85% identity to a corresponding non-loop region of an Fn3 sequence selected from the group consisting of SEQ ID NOs:
- 7-19 and 33-36 and (b) BC, DE, and FG loops of the Fn3 domain comprise of amino acid sequences 100% identical to corresponding BC, DE, and FG loops of the Fn3 sequence;
- and (2) DOTAGA, the DOTAGA being coupled to the polypeptide.
Dependencies are inferred from the claim text.