Human Placental Derived Natural Killer Cells with High Affinity and Cleavage Resistant CD16 and Secreted IL-15, and uses thereof

A vector comprising:

• (a) a first polynucleotide encoding a cleavage resistant CD 16 polypeptide operatively associated with a promoter;
• (b) a second polynucleotide encoding a secreted IL-15 polypeptide operatively associated with a promoter;
• or
• (c) a polynucleotide construct that ecodes a polypeptide comprising:
• (i) the amino acid sequence of a cleavage resistant CD16,
• (ii) the amino acid sequence of a T2A polypeptide, and
• (iii) the amino acid sequence of a secreted IL-15 polypeptide.