Quinazoline derivative compound and use thereof

A compound represented by the Chemical Formula 1 below, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

• in the Chemical Formula 1,
• R1 and R2 are each independently —H, —(C1-C6)alkyl, —(CH2)m—Rx, or —(C═O)—Rx {wherein, R1 and R2 cannot be methyl at the same time};
• Rx is —(C1-C6)alkoxy, —NRARB, -halo, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or heterohydroaryl {wherein at least one H in the cycloalkyl or heterocycloalkyl ring may be substituted with —(C1-C6)alkyl, —(C1-C6)hydroxyalkyl, —(C1-C6)alkyl-O—(C1-C6)alkyl, —(C═O)—(C1-C6)alkyl, —(C═O)—O—(C1-C6)alkyl, —NRCRD, —(═O)—, cycloalkyl, or benzyl, [wherein, at least one H in the benzyl ring may be substituted with —(C1-C6)alkyl, —(C1-C6)alkoxy, —(C1-C6)haloalkyl, or halo];
• at least one H in the aryl, heteroaryl, or heterohydroaryl ring may be substituted with —(C1-C6)alkyl, —(C1-C6)haloalkyl, or halo};
• RA and RB are each independently —H, —(C1-C6)alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl {wherein, at the least one H in the cycloalkyl, heterocycloalkyl, aryl, or heteroaryl ring may be substituted with —(C1-C6)alkyl};
• RC and RD are each independently —H or —(C1-C6)alkyl;
• m is 0, 1, 2, 3, or 4;
• R3 is —H, —(C1-C6)alkyl, —(C1-C6)alkoxy, or -halo;
• L is —NH(C═O)-L1-(CH2)n-L2-, —NH—S(═O)2-L1-(CH2)n-L2-, —(C═O)NH-L1-(CH2)n-L2-, -L1-(CH2)n-L2-(C═O)NH—, or —NH(C═O)NH—;
• L1 and L2 are each independently —CRERF—, —C(═O)NH—, or null;
• RE and RF are each independently —H, —(C1-C6)alkyl, —NH2, —NH(C═O)O—(C1-C6)alkyl, —OH, or -halo, or RE and RF are combined with carbon to form —(C3-C6)cycloalkyl;
• n is 0, 1, 2, 3, or 4;
• Z is aryl, heteroaryl, heterohydroaryl, cycloalkyl, heterocycloalkyl, or —(C2-C6)alkenyl {wherein, at least one H in the aryl, heteroaryl, or heterohydroaryl ring may be substituted with —(C1-C6)alkyl, —(C1-C6)haloalkyl, —(C1-C6)hydroxyalkyl, —(C1-C6)cyanoalkyl, —CN, —NRGRH, —(C1-C6)alkoxy, or -halo;
• at least one H in the cycloalkyl or heterocycloalkyl ring may be substituted with —(C1-C6)alkyl};
• RG and RH are each independently H or —(C1-C6)alkyl.