Viral vectors for nuclear reprogramming
AssigneeMayor Foundation for Medical Education and Research
InventorsPatricia Devaux, Yasuhiro Ikeda
Life of this patent
Estimating the term…
Abstract
This document provides materials and methods involved in making and using induced pluripotent stem cells (iPSCs). For example, measles virus vectors for reprogramming somatic cells into iPSC's, methods for obtaining iPSCs, and methods for using iPSCs are provided.
Claims9
(canceled)
A Paramyxoviridae viral vector for reprogramming somatic cells into iPSCs, wherein said vector comprises nucleic acid encoding a Paramyxoviridae leader sequence, nucleic acid encoding a Paramyxoviridae virus N polypeptide, nucleic acid encoding a Paramyxoviridae virus P polypeptide, nucleic acid encoding a Paramyxoviridae virus M polypeptide, nucleic acid encoding a Paramyxoviridae virus F polypeptide, nucleic acid encoding a Paramyxoviridae virus L polypeptide, nucleic acid encoding a Paramyxoviridae trailer sequence, and nucleic acid encoding a plurality of reprogramming factors located between said nucleic acid encoding said Paramyxoviridae virus F polypeptide and said nucleic acid encoding said Paramyxoviridae virus L polypeptide.
Dependencies are inferred from the claim text.