US 2026/0131062 A1 · ADVANCED METHODS AND SYSTEM FOR CONTROLLED WHOLE BODY HYPERTHERMIA

Abstract

An advanced system and methods for treatment of cancer and other diseases including complications from late-stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish a continuous extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. An innovative concept inherent in the instant invention is the incorporation of an ECMO machine to provide oxygenation. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed.

Claims63

Dependent claims

An advanced method for inducing controlled whole body hyperthermia in a patient, said method comprising:

a. slowly withdrawing a portion of blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit;
b. passing water or another heat exchange medium through a heat exchanger to heat the blood;
c. slowly heating blood passing through the extracorporeal circuit at a rate in the range from 0.05° C./min to 0.15° C./min in order to prevent vascular collapse until a target body core temperature in the range from 41.8° C. to 42.2° C. is achieved;
d. oxygenating the blood by using an oxygenating machine in order to combat respiratory failure and remove carbon dioxide from the blood;
e. maintaining the blood temperature at the target blood temperature for a treatment period in the range from 1 hour to 3 hours;
f. determining the target body core temperature as the mean value of the deep esophagus, right and left tympanic membranes, rectum, nasal-pharyngeal, and bladder temperatures, wherein the temperatures of the right and left tympanic membranes and nasal-pharyngeal temperatures are given a higher weight to ensure the brain does not overheat;
g. measuring the dose of heat delivered to the target tissue of the patient in terms of the Hyperthermia Treatment Unit (HTU);
h. maintaining an extracorporeal blood flow in the range of 1.5 to 3.0 L/min during the treatment period;
and
i. after the treatment period has ended, slowly and in a controlled manner cooling the blood until the body temperature has returned to 38° C. or below.

7 more elements

An advanced method for inducing hyperthermia to treat a condition in a seriously ill patient, said method comprising:

a. withdrawing only a portion of the patient's blood and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit;
b. heating blood passing through the extracorporeal circuit using a modular heater cooler to raise the patient's body core temperature to a target body core temperature in order to disrupt the intratumor microenvironment of cancerous tissue and thereby attenuate the spread of cancer cells;
c. oxygenating the blood with an oxygenation machine to counteract respiratory failure;
d. controlling the rate of heating and blood flow to within defined limits;
e. maintaining the elevated target body core temperature for a treatment period in the range from 1 hour to 3 hours;
f. temperature correcting the blood gases at the elevated core temperature
g. treating the blood with a standard dialysis or hemodiaultrafiltration process which combines a dialysis and plasma-pheresis process to introduce preselected slats selected to treat the metabolic condition;
h. detoxifying the blood by continuously passing it through a sorbent column and/or Tablo dialysis machine;
and
i. after the treatment period has ended, slowly cooling the blood until the core body temperature has returned to 38° C. or below.

7 more elements

An advanced method for inducing hyperthermia to treat a condition in a patient, said method comprising:

a. withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit;
b. heating blood passing through the extracorporeal circuit to raise the patient's body core temperature to a target body core temperature in order to disrupt the intratumor microenvironment of cancerous tissue and thereby attenuate the spread of cancer cells;
c. oxygenating the blood to counteract potential respiratory failure;
d. maintaining the target body core temperature for a treatment period in the range from 1 hour to 3 hours;
e. dialyzing the blood with a dialysate to introduce preselected salts selected to treat the particular condition, wherein the dialysate is maintained in a main reservoir and recycled through a dialysis circuit including a dialyzer that contacts the blood;
f. detoxifying the blood by a continuous flow through a sorbent column;
g. exchanging a replacement reservoir for the main reservoir after the dialysate in the main reservoir is exhausted, wherein the replacement reservoir becomes the main reservoir;
h. repeatedly replacing a new replacement reservoir for the main reservoir after the dialysate in the main reservoir becomes exhausted until the treatment period has ended;
and
i. after the treatment period has ended, cooling the blood until the body temperature has returned to 38° C. or below.

7 more elements

An advanced method for inducing hyperthermia to treat a condition in a patient, said method comprising:

a. withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit;
b. heating blood passing through the extracorporeal circuit to raise the patient's body core temperature to a target body core temperature in order to disrupt the intratumor microenvironment of cancerous tissue and thereby attenuate the spread of cancer cells;
c. controlling the rate of heating and blood flow to within defined limits in order to prevent cancer cells from overcoming the calories added to the diseased tissue if the heat is added too slowly and to prevent vascular collapse if the heat is added too quickly;
d. maintaining the target body core temperature for a treatment period in the range from 1 hour to 3 hours;
e. temperature correcting the blood gases at the elevated core temperature
f. dialyzing the blood in a dialyzer and dialysis circuit to introduce preselected salts selected to treat the metabolic condition;
g. moving the blood throughout the extracorporeal flow circuit by means of up to five pumps connected to a heart lung machine, wherein the five pumps further comprise a main pump (#1), a dialysis pump (#2), two dialysis bath pumps (#3 and #4), and an optional IV fluids pump (#5).
h. detoxifying the blood by continuously passing it through a charcoal, glass bead, or CytoSorb sorbent column;
i. oxygenating the blood to prevent respiratory failure;
and
j. after the treatment period has ended, cooling the blood until the body temperature has returned to 38° C. or below.

8 more elements

Dependencies are inferred from the claim text.

Advanced methods and system for controlled whole body hyperthermia

Life of this patent

Advanced methods and system for controlled whole body hyperthermia

Life of this patent

Abstract

Claims63