Compositions comprising textured patterns and methods of using the same

A system for guiding unidirectional movement of a first cell type in a sample having one or more different cell types, the system comprising:

• a surface defining a three-dimensional pattern of asymmetric topographical elements configured to bias actin polymerization within the first cell type when the sample is exposed to the surface for a predetermined time period;
• the asymmetric topographical elements biasing movement of cells of the first cell type in a first direction along the asymmetric topographical elements;
• and
• the asymmetric topographical elements biasing movement of cells of a second, different cell type in a second, different direction along the asymmetric topographical elements.

A system for inducing directional movement of a cell in a sample comprising different cell types, the system comprising:

• a three-dimensional pattern of asymmetric topographical elements arranged on a surface of a material, the asymmetric topographical elements biasing actin polymerization within the cell when the sample is contacted to the surface of the material;
• wherein the asymmetric topographical elements are configured to selectively guide movement of cells of a first cell type in a first direction along the asymmetric topographical elements and not guide cells different from the first cell type in the first direction;
• and
• wherein the asymmetric topographical elements are aligned along at least one of straight, curved, or circumferential paths on the surface.

A system for inducing healing of a wound from the skin or tissue of a subject, the system comprising:

• a composition having a contact side configured to contact the wound, at least a portion of the contact side defining a three-dimensional pattern of topographical elements, the topographical elements being aligned along at least one of straight, curved, or circumferential paths on the portion of the contact side and configured to:
• bias movement of a first cell type in a first direction along the topographical elements;
• and
• bias movement of a second cell type in a second, different direction along the topographical elements;
• wherein the topographical elements bias movement of the first cell type in the first direction along the topographical elements by:
• biasing actin polymerization within cells of the first cell type at, adjacent to, or proximate to the wound such that the cells of the first cell type unidirectionally move toward or away from a direction defined by the topographical elements.

A system for preferentially biasing unidirectional movement of cells having greater cell speed over cells having slower cell speed in a sample comprising cells moving at different speeds, the system comprising:

• a three-dimensional pattern of asymmetric topographical elements arranged on a surface of a material, the asymmetric topographical elements biasing actin polymerization within the cell when the sample is contacted to the surface of the material;
• wherein the asymmetric topographical elements are configured to selectively guide movement of cells moving at a faster speed in a first direction along the asymmetric topographical elements and less selectively guide cells moving at a slower speed in the first direction;
• wherein the asymmetric topographical elements are aligned along at least one of straight, curved, or circumferential paths on the surface;
• and
• wherein the asymmetric topographical elements comprise saw-toothed shaped elements.

A system for preferentially biasing unidirectional movement of cells based on differences in cell speed in a sample comprising cells moving at different speeds, the system comprising:

• a three-dimensional pattern of asymmetric topographical elements arranged on a surface of a material, the asymmetric topographical elements biasing actin polymerization within the cell when the sample is contacted to the surface of the material;
• wherein the asymmetric topographical elements are configured to selectively guide movement of cells moving at a faster speed in a first direction along the asymmetric topographical elements and selectively guide movement of cells moving at a slower speed in a second direction along the asymmetric topographical elements;
• wherein the asymmetric topographical elements are aligned along at least one of straight, curved, or circumferential paths on the surface;
• and
• wherein the asymmetric topographical elements comprise saw-toothed shaped elements.