Stabilization of virus-based therapeutic agent

Abstract

A virus-based active agent is mixed with trehalose and water and dried. The mixture may also contain one or more of pullulan and albumin. The mixture may be dried to a moisture content of 0.1-10%. The drying may be under vacuum sufficient to produce a foam. Some or all of the drying may be at a temperature in the range of 15-40° C., or at a temperature in the range of 1-15° C., or both. The active agent may be based on a vesicular stomatitis virus (VSV) or an adenovirus (AdV). The dried mixture may be stored at a temperature in the range of 1-55° C. A composition includes a virus, which may be a derived or modified form of a virus such as VSV or AdV. The composition also includes trehalose and optionally one or more of pullulan, and albumin. The composition may be used for a virus-based vaccine.

Dependencies are inferred from the claim text.