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US 2026/0130982 A1Published application
Methods for assembling protein-conjugated nanocarrier vaccines
AssigneeNorthwestern University
InventorsNeha Prashant Kamat, Vivian Hu, Susan Daniel, Hector Aguilar-Carreno, Ekaterina Selivanovitch, Shahrzad Ezzatpour
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Abstract
Provided herein are vaccine compositions for preparing nanocarriers comprising NiVF and NiVG virus proteins. Methods for preparing and using the nanocarriers for eliciting neutralizing antibodies or treating a Nipah virus infection are also described herein.
Claims43
A vaccine composition comprising:
- a nanocarrier comprising a membrane;
- a cell-free protein synthesis system;
- and
- at least one of a nucleic acid template encoding a NiVG protein comprising a transmembrane domain and a nucleic acid template encoding a NiVF protein comprising a transmembrane domain;
- wherein the NiVG transmembrane domain and the NiVF transmembrane domain are able to integrate into the nanocarrier membrane.
2 more elements
A vaccine composition comprising:
- a nanocarrier comprising a membrane;
- a cell-free protein synthesis system;
- and
- at least one of a nucleic acid template encoding a NiVG fusion protein and a nucleic acid template encoding a NiVF fusion protein,
- wherein the membrane comprises at least one of a first modified lipid and a second modified lipid;
- and
- wherein the NiVG fusion protein comprises a first protein tag that conjugates to the first modified lipid and a NiVG Nipah virus protein, and
- wherein the NiVF fusion protein comprises a second protein tag that conjugates to the second modified lipid and a NiVF Nipah virus protein.
5 more elements
Dependencies are inferred from the claim text.