Methods and compositions for treating and preventing respiratory related diseases and conditions with xylitol-headgroup lipid analogs
AssigneeNational Jewish Health
InventorDennis R. VOELKER
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Abstract
The invention generally relates to methods to prevent and/or inhibit viral infection as well as to inhibit inflammation and/or pathogen infection by administering at least one xylitol lipid analog or compositions comprising at least one xylitol lipid analog to an individual. The invention also relates to methods to prevent or inhibit respiratory syncytial virus (RSV) infection by administering at least one xylitol lipid analog or compositions comprising at least one xylitol lipid analog to an individual.
Claims16
1-42. (canceled)
A composition comprising at least one xylitol lipid analog, wherein the xylitol lipid analog has the following characteristics:
- a) has a phospholipid glycerol backbone;
- b) has a xylitol polar headgroup;
- c) has a phosphodiester bond linking the glycerol backbone to the xylitol polar headgroup;
- d) has variable hydrophobic regions comprising two aliphatic chains of 14 to 18 carbons in length, wherein linkage between the aliphatic chains and the phospholipid glycerol backbone is an O-acyl linkage or an O-alkyl linkage;
- and the aliphatic chains contain 0 to 2 double bonds.
A xylitol lipid analog comprising:
- a. a phospholipid glycerol backbone;
- b. a xylitol polar headgroup;
- c. a phosphodiester bond linking the glycerol backbone to the xylitol polar headgroup;
- and
- d. variable hydrophobic regions comprising two aliphatic chains of 14 to 18 carbons in length, wherein linkage between the aliphatic chains and the phospholipid glycerol backbone is an O-acyl linkage or an O-alkyl linkage;
- and wherein the aliphatic chains contain 0 to 2 double bonds.
Dependencies are inferred from the claim text.