Treatment of leishmaniasis

A compound of formula (I):

• wherein X1 is CR1, C(R1)2, N, NR1, O or S;
• X2 is CR2, C(R2)2, N, NR2, O or S;
• X3 is CR3, C(R3)2, N, NR3, O or S;
• X4 is a bond or NR4, O or S;
• L1 is optionally substituted C1-12 alkylene, optionally substituted C2-12 alkenylene, optionally substituted C2-12 alkynylene or -(L4O)mL5-;
• L2 is a bond or is optionally substituted C1-12 alkylene, optionally substituted C2-12 alkenylene, optionally substituted C2-12 alkynylene or -(L4O)mL5-;
• L3 is an optionally substituted 5 to 10 membered heteroarylene or an optionally substituted C6-10 arylene;
• L4 is optionally substituted C1-6 alkylene, optionally substituted C2-6 alkenylene or optionally substituted C2-6 alkynylene;
• L5 is a bond or optionally substituted C1-6 alkylene, optionally substituted C2-6 alkenylene or optionally substituted C2-6 alkynylene;
• R1, R2 and R3 are each independently H, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkynyl, optionally substituted C2-12 alkenyl, OR13, SR13, NR13R14, COR13, COOR13, CONR13R14, CN or a halogen;
• R4 is H, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkenyl or optionally substituted C2-12 alkynyl;
• R5, R7 and R8 are independently absent or H, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkynyl, optionally substituted C2-12 alkenyl, OR13, SR13, NR13R14, COR13, COOR13, CONR13R14, CN or a halogen;
• R6 is H, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkynyl, optionally substituted C2-12 alkenyl, OR13, SR13, NR13R14, COR13, COOR13, CONR13R14, CN or a halogen;
• R9 is absent or is H, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkenyl or optionally substituted C2-12 alkynyl;
• or R6 and R9 together with the atoms to which they are attached combine to form an optionally substituted 5 or 6 membered heterocycle or an optionally substituted 5 or 6 membered heteroaryl;
• R10 is H, halogen, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkenyl or optionally substituted C2-12 alkenyl;
• R11 is absent or H, halogen, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkenyl or optionally substituted C2-12 alkenyl;
• or R6 and R10 together with the atoms to which they are attached combine to form an optionally substituted 5 or 6 membered heterocycle or an optionally substituted 5 or 6 membered heteroaryl;
• or R10 and R11 together form an oxo group;
• R12 is NR13R14, an optionally substituted 5 to 10 membered heteroaryl or an optionally substituted 3 to 10 membered heterocycle, where the heteroaryl or heterocycle contain at least one nitrogen;
• R13 and R14 are independently H, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkenyl or optionally substituted C2-12 alkynyl;
• n is 0 or 1;
• and
• m is an integer between 1 and 5;
• or a pharmaceutically acceptable complex, salt, solvate, tautomeric form or polymorphic form thereof.