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US 2026/0124247 A1Published application
Methods for making auditory progenitor cells and uses thereof
AssigneeThe Regents of the University of California
InventorsAlireza MOSHAVERINIA, Sevda POURAGHAEI SEVARI
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Abstract
Methods are described for preparing auditory progenitor cells from gingival mesenchymal cells, for uses such as restoring hearing in hearing impaired individuals.
Claims49
A method of treating hearing loss associated with loss of sensory neurons in a human subject, the method comprising:
- a. obtaining a population of gingival mesenchymal stem cells (GMSCs);
- b. optionally expanding the population of GMSCs in vitro;
- c. encapsulating the population of GMSCs in an elastic three-dimensional scaffold;
- d. exposing the encapsulated population of GMSCs to a composition comprising one or more growth factors;
- e. allowing a sufficient period for the population of GMSCs to differentiate towards auditory progenitor cells;
- f. optionally retrieving the auditory progenitor cells from the scaffold;
- and
- g. introducing the auditory progenitor cells into the inner ear of the subject.
5 more elements
An in vitro method of generating auditory progenitor cells, the method comprising the steps of:
- a. obtaining a population of gingival mesenchymal stem cells (GMSCs);
- b. optionally expanding the population of GMSCs in vitro;
- c. encapsulating the population of GMSCs in an elastic three-dimensional scaffold;
- d. exposing the encapsulated population of GMSCs to a composition comprising one or more growth factors;
- e. allowing a sufficient period for the population of GMSCs to differentiate towards auditory progenitor cells;
- and
- f. retrieving the auditory progenitor cells from the scaffold.
4 more elements
Dependencies are inferred from the claim text.