Systems, Methods, and Apparatuses for Producing and Packaging Medical Fluids

A multi-compartment reservoir for medical agent comprising:

• a first and second wall sealed to one another at a peripheral seal to define an interior volume of the reservoir;
• a first port and a second port each formed of rigid material and defining an interior flow path in communication with the interior volume, each of the first port and second port having sets of integrally formed ribs extending therefrom and spaced apart along the axial dimension of the respective port, each set of ribs including a first rib and a second rib extending outwardly from opposing sides of the respective port, each of the ribs at least partially surrounding the respective port, the set of ribs on each port most distal the peripheral seal having a smallest cross-sectional area of any set of ribs on the respective port, each port including a coupling region having a pair of opposing spine projections, each port coupled into the peripheral seal at the coupling region;
• a septum coupled to an end of the first port most distal to the peripheral seal;
• a removal closure coupled to an end of the second port most distal to the peripheral seal a first compartment in fluid communication with the ports, the first compartment being collapsed and devoid of contents;
• a second compartment containing a concentrate;
• and
• a frangible partition separating the first and second compartment, first and second sheet being coupled together to form the frangible partition, the frangible portion being curved such that a central region of the frangible partition is most distal to the portion of the peripheral seal into which the first and second port are coupled, the peripheral seal including a first thickened region and a second thickened region on opposing sides of the reservoir, the frangible partition extending from the first thickened region to the second thickened region;
• and
• wherein the peripheral seal includes a marking region along a side of the peripheral seal into which the ports are coupled, the marking region being an island of unsealed first and second wall material which is surrounded by the peripheral seal on all sides.

An IV bag access port for coupling into a peripheral seal of an IV bag and providing a fluid communication pathway into the IV bag comprising:

• a port body extending along a longitudinal access, the port body having a bore extending therethrough, the bore of the port body having an Ra surface roughness of no greater than 0.1 μm, the port body being formed of a rigid, injection molded polymer,
• a set of wings extending outwardly from a coupling region on an exterior surface of the port body proximate a first end of the port body, the set of wings including a first wing and a second wing projecting from opposing sides of the coupling region, each wing defined by a first concavely curved surface and a second, opposing, concavely curved surface, the first and second concavely curved surfaces approaching one another as distance from the port body increases and being parallel to one another along a plane extending through the longitudinal axis, each of the wings being monolithically formed with the port body;
• a first set of ribs monolithically formed with the port body, the first set of ribs including a first rib and a second rib, the first rib and second rib extending outwardly from opposite sides of the port body such that the first set of ribs are symmetric about a plane of symmetry extending through the longitudinal axis of the port body;
• and
• a second set of ribs monolithically formed with the port body, the second set of ribs spaced apart from the first set of ribs along longitudinal axis of the port body such that the second set of ribs is most proximate a second end of the port body opposite the first end and the first set of ribs is most proximate the set of wings, the second set of ribs including a third rib and a forth rib extending outwardly from opposite sides of the port body such that the second set of ribs are symmetric about the plane of symmetry;
• and
• one of a list consisting of a septum and a removable closure coupled to the second end of the port body;
• and
• wherein each of the first set of ribs extend outwardly from the port body along respective first arcs and each of the second set of ribs extend outwardly from the port body along respective second arcs, the second arcs having a smaller arc length than the first arcs.